|
Malignant neoplasm of breast
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Prostate Cancer, Hereditary, 9
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
0.120 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of ovary
|
0.110 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
PROSTATE CANCER, SUSCEPTIBILITY TO
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Prostate cancer, familial
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This is the first description of a pleomorphic giant cell prostate cancer expressing HOXB13.
|
28484843 |
2017 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our group recently developed a transgenic murine model of prostate cancer involving prostate-specific Pten deletion and forced expression of MYC under the control of the Hoxb13 promoter.
|
29851094 |
2018 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HOXB13 and MEIS paralog expression in prostate epithelial cells and PCa cell lines was characterized by qPCR and immunoblot analyses.
|
30560549 |
2019 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Quantitative RT-PCR demonstrated the specificity of expression of HOXB13 in prostate tissue and revealed its ubiquitous expression in a series of 37 primary prostate cancers and 20 normal prostates.
|
15583692 |
2005 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Results from this study implicated a novel effect of ATRA in inhibition of the growth of AR(-) resistant human prostate cancer cells through alteration of HOXB13 expression as a result of epigenetic modifications.
|
22808286 |
2012 |
|
Malignant neoplasm of breast
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
No studies have been made regarding the HOXB13 protein levels in breast cancer.
|
20649975 |
2010 |
|
Malignant neoplasm of breast
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen.
|
17308270 |
2007 |
|
Malignant neoplasm of breast
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our epigenetic analysis has found that increased promoter methylation of one of these genes, HOXB13, correlate with the decreased expression of its transcript in breast cancer cell lines (P < 0.005).
|
18499701 |
2008 |
|
Malignant neoplasm of breast
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer.
|
15193263 |
2004 |
|
Malignant neoplasm of breast
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A HOXB13-to-IL17BR expression ratio was previously identified to predict a clinical outcome of breast cancer patients treated with adjuvant tamoxifen.
|
24264313 |
2014 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A HOXB13-to-IL17BR expression ratio was previously identified to predict a clinical outcome of breast cancer patients treated with adjuvant tamoxifen.
|
24264313 |
2014 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer.
|
15193263 |
2004 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our epigenetic analysis has found that increased promoter methylation of one of these genes, HOXB13, correlate with the decreased expression of its transcript in breast cancer cell lines (P < 0.005).
|
18499701 |
2008 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen.
|
17308270 |
2007 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
No studies have been made regarding the HOXB13 protein levels in breast cancer.
|
20649975 |
2010 |
|
Prostatic Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Partitioning the genome according to cistromes reveals the enrichment of somatic SNVs in prostate tumors as opposed to adjacent normal tissue cistromes of master transcription regulators, including AR, FOXA1, and HOXB13.
|
31735626 |
2019 |
|
Prostatic Neoplasms
|
0.380 |
AlteredExpression
|
group |
LHGDN |
HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.
|
15126340 |
2004 |
|
Prostatic Neoplasms
|
0.380 |
AlteredExpression
|
group |
LHGDN |
HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.
|
15604291 |
2004 |
|
Prostatic Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
To identify HOXB13 transcriptional targets in metastatic PCs, we performed integrative bioinformatics analysis of differentially expressed genes (DEGs) in the proximity of the human prostate tumor-specific AR binding sites.
|
31273254 |
2019 |